For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

imageimageSTING inhibits LINE-1 retrotransposition to maintain genomic stability in an IFN-independent manner. STING interacts with LINE-1 ORF1p, sorting ORF1p to lysosomes for degradation. STING ...

Although asymptomatic malaria was historically perceived as innocuous, emerging evidence revealed an immunosuppressive signature induced by asymptomatic Plasmodium falciparum infections. To examine if ...

imageimageSynovial sarcomas is a rare aggressive cancer characterized by aberrant SS18::SSX translocation and altered chromatin accessibility. This multi-screen study identifies SUMO2 as a critical ...

imageimageIn mouse spermatocytes, the X and Y chromosomes undergo rapid non-homologous synapsis and desynapsis during early pachynema. This study reveals that X-Y desynapsis initiated by the atypical ...

Dynamic reorganization of synaptic vesicles, synapsins, and actin is tightly associated with synaptic activity, but the molecular details of their interactions are not fully understood. This study ...

Essentiality studies have traditionally focused on coding regions, often overlooking other small genetic regulatory elements. To address this, we combined transposon libraries containing promoter or ...

Loss of pluripotency is an essential step in post-implantation development that facilitates the emergence of somatic cell identities essential for gastrulation. Before implantation, pluripotent cell ...

imageimageThe GndRX system in Legionella pneumophila is a predicted toxin-antitoxin module that causes death during DNA stress. GndRX has non-canonical functionality and appears to be the consequence ...