Viktor Gyokeres leads the line for Arsenal, finally making his Premier League debut despite spending four seasons at Brighton and Hove Albion earlier in his career. He is not the only fresh face in the Gunners' lineup, though, with Martin Zubimendi slotting into a place in midfield. See Arsenal's starters and substitutes below.

Manchester United is 102-51-90 against Arsenal, though they lost and drew with the Gunners in league play last season. Time: 11:30 a.m. ET Where: Old Trafford (Manchester, U.K.)