The model is based on a structure previously solved of DCAF16-DDB1-DDA1 in complex with BRD4 in the presence of an electrophilic BRD4 molecular glue degrader MMH2 (PDB: 8g46) (35) that did not include ...

Protein–protein interactions are no longer considered undruggable because of the conceptual and technical advances that allow inhibitors to be generated using rational design principles and ...