Officials are moving forward with the final phase of the Portals Complex in Southwest Washington, D.C.

Northwestern University biophysicists have developed a new computational tool for identifying the gene combinations underlying complex illnesses like diabetes, cancer and asthma.

Researchers developed a biomimetic nanovesicle that crosses the blood-brain barrier, degrades DNA repair proteins, and restores temozolomide sensitivity in glioblastoma.

BRD4, a member of the BET protein family, plays a critical role in cancer progression by regulating oncogenes, particularly MYC, which drives tumor growth but is difficult to target directly.

Our findings suggest that the interaction of lncBARTs with the BRD4-CTCF complex could impact the epigenetic reprogramming of host cells. Importantly, ATAC and transcriptome analyses indicated that ...

“Our selective BRD4 (BD2) inhibitor, DC-9476, demonstrates a potentially new strategy to treat MAS by directly inhibiting macrophage activation,” said Kfir Schreiber, CEO & Co-Founder of DeepCure.

BOSTON-- (BUSINESS WIRE)-- #AI -- DeepCure, a therapeutics company using AI to discover novel drugs for inflammation and immune diseases, today announced it will present early safety and efficacy data ...

Breakthrough in complex pain management 80% recovery with early diagnosis and best practice treatment Date: April 30, 2024 Source: University of South Australia Summary: Complex Regional Pain ...

Simcere Zaiming Pharmaceutical Co. Ltd. has divulged proteolysis targeting chimera (PROTAC) compounds comprising a cereblon E3 ubiquitin ligase binding moiety coupled to a probable global ...

Cellular adaptation to hypoxic stress requires hypoxia-specific gene expression programs, ultimately enacted via control of transcriptional elongation. However, the specific CDK9-containing complex ...

The researchers showed that the BRD4-S mRNA expression positively correlated with BRD4-S protein levels, while BRD4-L isoform showed negative correlation between mRNA and protein levels.