A local cancer treatment center is giving patients across West Texas renewed hope by highlighting the life-saving potential of clinical trials.

The Odessa American is the leading source of local news, information, entertainment and sports for the Permian Basin.

The Odessa American is the leading source of local news, information, entertainment and sports for the Permian Basin.

This afternoon, Iskander-M OTRK delivered a high-precision strike with two ballistic missiles on the infrastructure of the ...

Discover the best staycation spots in Odessa, TX—from cabin rentals to hot tub suites. Local escapes that feel miles away ...

Russia launched two ballistic missiles toward the port of Odessa, resulting in the death of one person and injuries to eight ...

Russia launched two ballistic missiles towards the port of Odessa, resulting in the death of one person and injuries to eight ...

A 33-year-old Odessa man has been arrested for crimes related to the sexual assault of a child, according to the Odessa ...

In observance of Memorial Day, the following City Offices will be closed on Saturday, May 24: Odessa Animal Shelter, Household Hazardous Waste, and the Odessa Recycling Center. City offices that will ...

For this week’s Basin Bites, we visited Brunch and Munch Eatery and Creperie, an Odessa gem that’s just as much about the ...

In Odessa, a series of several explosions once again sounded, which, apparently, were the result of a Russian missile attack.

Greece's Prime Minister Kyriakos Mitsotakis has accepted President Zelensky's invitation to attend the Ukraine-Southeastern ...