Texans head coach DeMeco Ryans is a former 49ers defensive coordinator under Kyle Shanahan, so San Francisco knows how difficult of a challenge it will be against Houston. Jones went into further detail about the Texans, highlighting their linebackers in particular.

The San Francisco 49ers (5-2) visit the Houston Texans (2-4) Sunday in Week 8. Kickoff from NRG Stadium in Houston, Texas, is at 1 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the 49ers vs. Texans odds and make our expert NFL picks and predictions for the best bets.

The San Francisco 49ers, led by quarterback Mac Jones, face the Houston Texans, led by quarterback C.J. Stroud, on Sunday, Oct. 26, 2025 at NRG Stadium in Houston, Texas.

The Houston Texans are back on the field during a short week against the San Francisco 49ers to start a three-game home stand, where the pressure is high for Houston to get back on track following a 2-4 start through seven weeks.

The Seattle Seahawks (5-2) triumphed 27-19 over the Houston Texans (2-4) in a game that wasn't as close as the scoreboard indicated. Seattle struggled to get out of their own way, committing four turnovers -- their most in a game since 2020.

Deshaun Watson's career after leaving the Houston Texans has taken another dour but noteworthy turn as he recovers from his latest injury.

According to a team announcement, the Texans have waived tight end Brenden Bates. Bates, a 6-foot-5, 26-year old tight end, started his career as an undrafted free agent and was signed onto the Texans roster earlier in September from the Cleveland Browns' practice squad for some extra depth at the position.