Morning Overview on MSN

Fifteen baffling mysteries science still cannot explain

I have always been drawn to the strange edge cases where our best theories simply do not fit the facts. From mysterious ...
Nature

The reverse stop-signal model for CTLA4 function

Cytotoxic T-lymphocyte antigen 4 (CTLA4) is a co-receptor expressed by activated, memory T cells and regulatory T cells 1,2,3,4,5,6. It is a homodimer that can bind to the homodimeric ligands CD80 ...

Phi-4 proves that a 'data-first' SFT methodology is the new differentiator

The Phi-4 model was trained on just 1.4 million carefully chosen prompt-response pairs. Instead of brute force, the Microsoft ...

INTRODUCING THE ALL-NEW 2027 KIA TELLURIDE: FIRST-EVER HYBRID, INCREASED X-PRO CAPABILITY ELEVATE THE THREE-ROW SUV

Today, Kia unveiled the upcoming next-generation 2027 Telluride SUV at the 2025 Los Angeles Auto Show. The confident and ...
Morning Overview on MSN

It looks ancient Egyptian, but this marvel stands in Peru

From a distance, a stepped stone silhouette on Peru’s coast can look uncannily like something lifted from the Nile. The resemblance is striking enough that visitors often reach for Egyptian ...
eLife

Multi-barrier unfolding of the double-knotted protein, TrmD–Tm1570, revealed by single-molecule force spectroscopy and molecular dynamics

This study investigates the folding and unfolding behavior of the doubly knotted protein TrmD-Tm1570, providing insight into the molecular mechanisms underlying protein knotting. The findings reveal ...