A review paper published last year in European Journal of Medicinal Chemistry characterized Myc as the “oncogene from ...

Does MYC binding to chromatin serve transcription-independent functions, including the regulation of chromosomal integrity, gene expression, chromatin structure, cellular replication and genomic ...

researchers have known that the MYC protein is implicated in more than half of all cancers, including breast, brain and prostate. However, it has remained an elusive target as its structure has been ...

N-Myc is difficult to target in part because its structure is more malleable than that of a rigid protein. Additionally, it is not an enzyme—meaning it doesn’t have a predetermined pocket ...

On the other hand, a random C-terminal tag does not significantly affect GFP folding, whereas the N-terminal myc-tag severely ... of maintaining intact the protein structure under study.