A review paper published last year in European Journal of Medicinal Chemistry characterized Myc as the “oncogene from ...

Does MYC binding to chromatin serve transcription-independent functions, including the regulation of chromosomal integrity, gene expression, chromatin structure, cellular replication and genomic ...

N-Myc is difficult to target in part because its structure is more malleable than that of a rigid protein. Additionally, it is not an enzyme—meaning it doesn’t have a predetermined pocket ...

“We see firsthand that even when two patients both have MYC on ecDNA, the structure of that circular ... higher levels of the cancer-promoting MYC protein (red) also tend to exhibit high levels ...

researchers have known that the MYC protein is implicated in more than half of all cancers, including breast, brain and prostate. However, it has remained an elusive target as its structure has been ...

On the other hand, a random C-terminal tag does not significantly affect GFP folding, whereas the N-terminal myc-tag severely ... of maintaining intact the protein structure under study.