eLife

Increased layer 5 Martinotti cell excitation reduces pyramidal cell population plasticity and improves learned motor execution

This valuable study addresses a critical and timely question regarding the role of a subpopulation of cortical interneurons (Chrna2-expressing Martinotti cells) in motor learning and cortical dynamics ...

Absence of evidence is not evidence of absence – and that affects what scientific journals choose to publish

If the claim is really false but the researcher decides, based on the evidence, it’s true – a false positive – they commit what’s called a Type 1 error. If the claim is really true but the researcher ...

Wish list 2025: How you can help local nonprofits this holiday season

As you plan your holiday giving this year, PennLive encourages you to take a look at its annual “Wish List” of goods and ...
eLife

Natural xanthones as α-Mangostin induce vasorelaxation via binding to key gating residues in the S6 domain of BK channels

The present manuscript by Cordeiro et al., shows convincing evidence that α-mangostin, a xanthone obtained from the fruit of the Garcinia mangostana tree, behaves as a strong activator of the ...