Compatibility mode is a Windows 11 feature that simulates older Windows versions for your programs. This allows you to run old software on your Windows 11 machine.

Locate the program icon, right-click it, and select Properties from the list of options displayed. Locate the Compatibility option, and then under Compatibility mode, tick the box next to Run this ...

If you cannot open and run any Program when you click on it, maybe soon after login or after Windows Update in Windows 11/10 take these steps to fix the issue.