If applicable to psychotic disorders, such bias would jeopardize the reliability of randomized clinical trials (RCTs) investigating antipsychotics and thus their extrapolation to clinical practice.

Background: Clinical trials are commonly done without blinded outcome assessors despite the risk of bias. We wanted to evaluate the effect of nonblinded outcome assessment on estimated effects in ...

A lack of blinding can result in observer bias in randomized controlled trials with subjective outcomes.

Conclusions: There is publication bias in colorectal cancer studies. Almost one-third of colorectal cancer RCTs presented at ASCO Annual Meetings remain unpublished after several years. Negative ...

Background: The reporting of outcomes within published randomized trials has previously been shown to be incomplete, biased and inconsistent with study protocols. We sought to determine whether ...

A new study of randomized clinical trials found significant observer bias toward a more beneficial treatment effect in nonblinded trials when the researcher knew the treatment being given to the ...

Optimism bias in the design of phase III randomized control trials (RCTs) evaluating PD-1/PD-L1 targeting monoclonal antibodies (mAbs).

Of these, the authors found that 41 (76%) were randomized, controlled trials while 39 had available publications and were therefore included in the study.

The biologic and biosimilar era has brought about more clinical trials in rheumatology than ever before, and with increasing awareness and diagnostics, clinicians are identifying more patients ...