Pfizer has terminated a Phase I trial of its investigational STING therapy in advanced solid tumors, according to an update ...

The cGAS–STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes that can lead to ...

While short bursts of STING-mediated inflammation are crucial, in some people this pathway is chronically "on," a state that ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

Triggered by an enzyme called DNA protein kinase (DNA-PK), the newly found pathway is independent of the cGAS-STING pathway—until now considered the main regulator of mammalian innate immune responses ...