When the fridge door is opened the switch contact is closed, allowing current to flow, completing the circuit and activating the light. Figure caption, Push-to-make (PTM) and push-to-break (PTB ...
The solution structure of the dNumb phosphotyrosine binding (PTB) domain bound to a novel peptide ... state of a Tyr residue as a binary switch for binding target peptides. Specificity for ligand ...