The cycle progression is extensively controlled by the pRB/E2F signaling pathway. E2F is released from the pRB/E2F complex with the phosphorylation of pRB by cyclin–cyclin-dependent kinase (CDK ...
A multistep pathway, involving phosphorylation of pRB by cyclin-dependent kinases and release of E2F transcription factors required for DNA synthesis, culminates in progression from the G 1 to the ...
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