The H3K4me3–MLL1 interaction occurs at a different site on PHD3, enabling a ternary complex to form and CyP33 to recruit HDAC1. This complex is essential for MLL1-mediated repression of HOX gene ...
recent work has revealed that it binds an arginine-bearing motif in MLL1, promoting complex assembly and activity. These findings suggest that WDR5 functions as a peptidyl arginine–recognition ...
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