This study fills a crucial gap in our understanding of blood cell formation from human pluripotent stem cells (hPSCs). Genome-wide comparisons of hPSC-derived blood progenitor cells with in vivo blood ...

View Full Profile. Learn about our Editorial Policies. Hematopoietic stem cells (HSCs) are multipotent progenitor cells found in the blood and bone marrow. They have the ability to self-renew, and ...

A Ludwig Cancer Research study has identified a novel strategy for treating acute myelogenous leukemia (AML), an aggressive ...

We discovered that interferon gamma (IFNγ) promotes hematopoietic stem cell (HSC) division and myeloid differentiation in a mouse model of Mycobacterium avium infection (Nature 2010). Furthermore, ...

and their supporting function for normal hematopoietic cells in Notch1-induced acute T-cell lymphocytic leukemia (T-ALL) mice. We demonstrate that the proliferative capability and differentiation ...

and others that regulate self-renewal and differentiation. This work has led us to study the effects of stress, such as infection or age, on hematopoietic stem cells, using gene expression profiling ...