Context: Fatal familial insomnia (FFI) is a genetically transmitted neurodegenerative prion disease that incurs great suffering and has neither a treatment nor a cure. The clinical literature is ...

Causes: FFI is a neurodegenerative prion disease that is caused by a mutation ... Related: Not all insomnia is the same — in ...

At 1 week of age, the mice were infected with a mouse-passaged scrapie strain that causes fatal prion disease. By 8 weeks after inoculation, the infected mice showed deficiencies in hippocampus ...

Lachlan Webb was diagnosed with the incurable genetic disease fatal familial insomnia (FII ... FII is an incredibly rare prion protein gene mutation that has plagued Mr Webb’s family for ...

The chief clinical features of FFI include a progressive and ferocious insomnia, waking "sleep," hallucinations, autonomic disturbances suggestive of sympathetic overdrive (tachycardia ...