The New England Journal of Medicine

Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A

The goal of gene therapy for patients with hemophilia A is to safely impart long-term stable factor VIII expression that predictably ameliorates bleeding with the use of the lowest possible vector ...
Nature

Signal-dependent dynamics of transcription factor translocation controls gene expression

Information about environmental stimuli is often transmitted using common signaling molecules, but the mechanisms that ensure signaling specificity are not entirely known. Here we show that the ...
Healio

Investigational gene therapy leads to sustained factor VIII expression in hemophilia A

Please provide your email address to receive an email when new articles are posted on . The novel gene therapy SPK-8011 induced sustained factor VIII expression in patients with hemophilia A, ...
ascopubs.org

Reduced integrin alpha3 expression as a factor of poor prognosis of patients with adenocarcinoma of the lung.

Expression of the retinoblastoma-related gene Rb2/p130 correlates with clinical outcome in endometrial cancer. The ratio of integrin alpha3/beta-actin expression ranged from 0 to 5.87 (mean was 0.80; ...