When Grey's Anatomy took off as a cultural phenomenon in the mid-2000s, Patrick Dempsey's Dr. Derek Shepherd also swiftly became one of the biggest heartthrobs on television. Nicknamed "McDreamy ...

Grey's Anatomy first premiered on March 27, 2005, and has remained a powerhouse medical drama ever since.Fans immediately fell in love with the OG surgical interns, including Meredith, Cristina, Izzie ...

Kate Walsh played Derek Shepherd's ex-wife, Dr. Addison Montgomery, on the series from 2005-2012 Georgia Slater is a staff editor on the Parents team at PEOPLE. She has been working at PEOPLE ...

Ellen Pompeo stunned everyone with her words. The love interest of Dr. Derek Shepherd, aka McDreamy, made a recent appearance at a podcast during which she made shocking confessions. Golden Globe ...

She is the sister of Dr. Derek Shepherd (Patrick Dempsey). Introduced in season 9, Dr. Leah Murphy was featured on Grey's Anatomy for two seasons, and then returned for a new run in season 13.

Dr. Derek Shepherd’s on-screen love interest is busy celebrating 20 years of ABC's long-running medical drama and the release of her new series Good American Family. During her appearance at ...

11. "Meredith." Never before has one word been so shocking. After dying in season 11, we thought we would never see Derek Shepherd again, but the Grey's Anatomy writers had different plans.