Interestingly, CTLA-4 knockout mice and mice that lack expression of CTLA-4 just in T REG develop fatal, early-onset lymphoproliferative disease. 1,4 In addition, expression and signaling of CTLA ...

Two neoadjuvant immunotherapy combinations for head and neck cancer substantially increased the response rate versus a single ...

Anti-PD-1 and anti-CTLA-4 are common drugs in treating cancers like melanoma ... such as targets for PD-1 and lymphocyte activation gene-3. “There is a lot of room to expand Cyclone to precisely ...

But in the course of that work, performed at the University of California, Berkeley, Allison discovered that a protein receptor called CTLA-4 negatively regulated T-cell responses to antigens, and ...