Beibei Liu, Xinhua Liu, Lulu Han, Xing Chen, Xiaodi Wu, Jiajing Wu, Dong Yan, Yue Wang, Shumeng Liu, Lin Shan, Yu Zhang, Yongfeng Shang Proceedings of the National Academy of Sciences of the United ...
New research is advancing understanding of certain cancers and complex congenital disorders by illuminating how BRD4, a protein that scientists have studied for years, directs the spatial organization ...
“This evidence strengthens the relevance of the findings by Pietrobono et al., shedding light on the potential application of SMO inhibitors in concert with BRD4 inhibitors.” The Hedgehog-GLI (HH/GLI) ...
It started with wine. Or more precisely, a conversation about it. "My colleagues and I were talking about how some people think drinking wine may be anti-inflammatory," recalls Xu Zhou, Ph.D., from ...
Scientists have used an unconventional approach to cancer drug discovery to identify a new potential treatment for acute myeloid leukemia (AML), an aggressive blood cancer that is currently incurable ...
A new study, published in JCI Insight, looks at how Brd4, a regulator of the innate immune response, influences diet-induced obesity. The researchers believe that Brd4 could be used as a target for ...
Simcere Zaiming Pharmaceutical Co. Ltd. has divulged proteolysis targeting chimera (PROTAC) compounds comprising a cereblon E3 ubiquitin ligase binding moiety coupled to a probable global ...
BOSTON & HANGZHOU, China--(BUSINESS WIRE)--Ranok Therapeutics, a clinical-stage biopharmaceutical company that is developing a novel approach to targeted protein degradation for the treatment of ...
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