Still, McCaffery has been one of the healthier running backs for San Francisco during training camp. The 49ers already have put Patrick Taylor Jr. on injured reserve, gone most of the preseason without Jordan James and have only recently had Isaac Guerendo return from a shoulder injury.

The San Francisco 49ers are still trying to get their players healthy from last season, but they cannot avoid the injury bug at all. The team has been derailed

"One of the more underrated players nationally, Lenoir is special as a slot defender for the 49ers but can also lock up receivers on the perimeter. According to Next Gen Stats, Lenoir did not give up a touchdown pass and totaled two interceptions in 317 coverage snaps at slot defender in 2024, holding opposing quarterbacks to a 63.6 passer rating.

Charlotte 49ers defensive lineman Jamar Holley, center, celebrates the team’s play during fourth-quarter action against the East Carolina Pirates on Saturday, October 5, 2024 at Jerry Richardson Stadium in Charlotte, NC. The 49ers defeated ECU 55-24.

Los Angeles Chargers' quarterback Trey Lance needs to make a strong showing against the team that drafted him No. 3 overall in 2021.

This is not to say he should be a first-round pick. In fact, he shouldn't be an any-round pick before the last one when everyone is taking their kicker, defense or some crazy flyer. It's also worth noting Wilson hasn't even secured a 53-man roster spot after signing ahead of the 49ers' second preseason game vs. the Las Vegas Raiders.

The San Francisco 49ers completed a trade earlier in the week, acquiring wide receiver Skyy Moore from the Kansas City Chiefs. Here's why they did it.

The San Francisco 49ers have some injury issues, and here are two surprise preseason roster cuts to watch before Week 1.